The Impact of Various Types of Α-Thalassemia οn Perinatal Complications and Pregnancy Outcomes in Pregnant Women
St-Georges, J., Alnoman, A., Badeghiesh, A., & Baghlaf, H. Archives of Gynecology and Obstetrics, 311(5), 1343-1349. (2025)
Abstract
This study aims to investigate the adverse effects of different types of α-thalassemia on pregnant women and their differences, so as to provide a reference for the prevention and monitoring of perinatal complications in different types of α-thalassemia.
The observation group comprised 1371 singleton pregnant women with α-thalassemia; the control group comprised 680 non-thalassemia singleton pregnancies during the same period. The thalassemia genotypes of the observation group were tallied and categorized based on their respective genotypes within the group.
The haemoglobin in the experimental group was lower than in the control group. The incidences of electrocardiographic abnormality, abnormal liver function, hypertensive disorders, gestational diabetes mellitus and thyroid disorders during pregnancy were higher in the observation group than in the control group. The incidences of preterm labour, caesarean section and postpartum haemorrhage were all higher in the observation group than in the control group. The delivery weight and neonatal haemoglobin in the observation group were lower than those in the control group.
Pregnant women with α-thalassemia have more pregnancy and delivery complications than those without α-thalassemia; they should receive more frequent and standardized prenatal examinations to find and correct abnormal indicators in time.
