Publications
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The Influence of Cardiovascular Risk Factors and Hypogonadism on Cardiac Outcomes in an Aging Population of Beta-Thalassemia Patients
Beta-thalassemia major (β-TM) is a hereditary genetic disease worsened by many comorbidities due to transfusion-related iron despite chelation therapy. Since there has recently been an increase in life expectancy of…
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Hepatocellular Carcinoma in Transfusion Dependent Thalassemia Patients: A Review from a Clinical Perspective
Survival in patients with transfusion-dependent thalassemias (TDT) has increased, and complications such as hepatocellular carcinoma (HCC) are emerging. Risk factors include viral infection, mainly hepatitis C virus (HCV), iron overload,…
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Phylogenetic Analysis in the Clinical Risk Management of an Outbreak of Hepatitis C Virus Infection Among Transfused Thalassaemia Patients in Italy
Occurrence of hepatitis C virus (HCV) infection is reduced by effective risk management procedures, but patient-to-patient transmission continues to be reported in healthcare settings. To report the use of phylogenetic analysis in the…
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Renal Function in β-Thalassemia Major Patients Treated with Two Different Iron-Chelation Regimes
Background Renal injury in transfusion dependent β thalassemia patients (TDT) has been attributed to iron overload, chronic anemia and iron-chelation therapy (ICT) toxicity. We studied renal function in TDT patients…
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Prenatal Diagnosis Leads to Early Diagnosis of Transfusion-Dependent Thalassemia and Better Growth Outcomes
Thalassemia is the most common hematological transfusion-dependent disease in Thailand. Even though prenatal diagnosis (PND) can detect the condition, many new cases are diagnosed in pediatric practice. This study assessed…
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Glucose Metabolism and Insulin Response to Oral Glucose Tolerance Test (OGTT) in Prepubertal Patients with Transfusion-dependent β-Thalassemia (TDT): A Long-term Retrospective Analysis
Glucose dysregulation (GD), including prediabetes and diabetes mellitus (DM), is a common complication of transfusion-dependent β-thalassemia (TDT) patients. The prevalence increases with age and magnitude of iron overload, affecting a…
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Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus
Initiation of regular transfusion in transfusion-dependent thalassemia (TDT) is based on the assessment of clinical phenotype. Pathogenic HBB variants causing β-thalassemia are important determinants of phenotype and could be used to aid…
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The Transfusion Management of Beta Thalassemia in the United States
These are the first recommendations directed toward hematologists and transfusion medicine specialists that are designed to specifically address concerns that are pertinent to the thalassemia population in the U.S. Here,…
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Pregnancy Outcomes in Women Affected by Fetal Alpha-Thalassemia: A Case Control Study
To evaluate the possible associations between fetal α-thalassemia and risk of adverse pregnancy outcomes using a provincial woman-child health service information database in China. This was a case control study…
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How to Facilitate Decision-Making for Hematopoietic Stem Cell Transplantation in Patients With Hemoglobinopathies. The Perspectives of Healthcare Professionals
Hematopoietic stem cell transplantation decision-making for hemoglobinopathy patients is a complex process, and it remains difficult for health care professionals to decide whether and when a hematopoietic stem cell transplantation…
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