Publications
-
Global Globin Network Consensus Paper: Classification and Stratified Roadmaps for Improved Thalassaemia Care and Prevention in 32 Countries
The Global Globin Network (GGN) is a project-wide initiative of the Human Variome/Global Variome Project (HVP) focusing on haemoglobinopathies to build the capacity for genomic diagnosis, clinical services, and research…
Read More » -
Pregnancy Outcomes Among Women Affected with Thalassemia Traits
Objective To compare the maternal and perinatal outcomes between a group of pregnant women diagnosed with thalassemia traits and normal controls. Study design A retrospective cohort study was conducted on…
Read More » -
Early Detection of Iron Overload Cardiomyopathy in Transfusion Dependent Thalassemia Patients in Sulaimaniyah City, Iraq
Lifelong blood transfusion is recommended for patients with transfusion-dependent thalassemia (TDT) that lead to iron overload and results in cardiomyopathy (CM). The aim of this study is to assess the…
Read More » -
Transfusion Complications in Thalassemia: Patient Knowledge and Perspectives
Chronic transfusion, used to manage clinically significant forms of thalassemia, carries complication risks including iron overload, alloimmunization, and allergic or hemolytic reactions. Dissemination and implementation of evidence-based guidelines for minimizing…
Read More » -
Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease
BACKGROUND Sickle cell disease is characterized by the painful recurrence of vaso-occlusive events. Gene therapy with the use of LentiGlobin for sickle cell disease (bb1111; lovotibeglogene autotemcel) consists of autologous…
Read More » -
Iron Overload Status in Patients with Non-Transfusion-Dependent Thalassemia in China
Background: Non-transfusion-dependent thalassemia (NTDT) is a genetic disorder most commonly including beta-thalassemia intermedia (Beta-TI), HbE/Beta thalassemia (HbE/Beta thalassemia), and hemoglobin H disease (HbH disease). NTDT patients can be at risk of…
Read More » -
Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations
Reports of nutritional deficiencies in patients with thalassemia (Thal) are common. Despite its importance, however, nutritionally focused research in Thal has been limited by inadequate sample size, inconsistent methodology, a…
Read More » -
-
Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management
Atrial fibrillation in patients with β-thalassemia has a higher incidence compared to the general population. Its pathophysiology is peculiar and strictly related to anemia, iron overload, hemolysis, inflammation, atrial dilatation,…
Read More » -
Guidelines for the Monitoring and Management of Iron Overload in Patients with Haemoglobinopathies and Rare Anaemias
These Guidelines were compiled according to the BSH process at https://b-s-h.org.uk/guidelines/proposing-and-writing-a-new-bsh-guideline/. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclaturewas used to evaluate levels of evidence and to assess…
Read More »