Catherine Skari

Setting up and Sustaining Blood and Marrow Transplant Services for Children in Middle-Income Economies: An Experience-Driven Position Paper on Behalf of the EBMT PDWP

Severe blood disorders and cancer are the leading cause of death and disability from noncommunicable diseases in the global pediatric…

Read More »

Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City

Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that is very common and causes a great burden in…

Read More »

Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized…

Read More »

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

Transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are severe monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is…

Read More »

The Prevention of Thalassemia Revisited: A Historical and Ethical Perspective by the Thalassemia International Federation

Hemoglobinopathies are the most common monogenic disorders in humans; among them, thalassemia constitutes a serious medical and public health problem…

Read More »

Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations

Reports of nutritional deficiencies in patients with thalassemia (Thal) are common. Despite its importance, however, nutritionally focused research in Thal…

Read More »

Gene Therapy of the Hemoglobinopathies

Sickle cell disease and the ß-thalassemias are caused by mutations of the ß-globin gene and represent the most frequent single…

Read More »

Challenging the Erythropoiesis Paradigm in β-Thalassemia

β-thalassemia is a genetic disorder due to defective β-globin synthesis that results in severe anemia. A hallmark of the disease…

Read More »

Effects of A-Tocopherol on Hemolysis and Oxidative Stress Markers on Red Blood Cells in β-Thalassemia Major

The accumulation of unpaired α-globin chains in patients with β-thalassemia major may clinically create ineffective erythropoiesis, hemolysis, and chronic anemia.…

Read More »

Recommendations for Pregnancy in Rare Inherited Anemias

Rare inherited anemias are a subset of anemias caused by a genetic defect along one of the several stages of…

Read More »