Publications
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A Short Guide for the Management of Transfusion-Dependent Thalassaemia (2nd edition – 2022)
Prepared by: Farmakis, D. Reviewed by: Eleſtheriou, A., Bain, B.
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Frequency, Pattern, and Associations of Renal Iron Accumulation in Sickle/β-Thalassemia Patients
We evaluated frequency, pattern, and associations of renal iron accumulation in sickle/β-thalassemia. Thirty-three sickle/β-thalassemia patients (36.5 ± 14.7 years; 13 females), 14 homozygous sickle cell disease (SCD) patients, and 71 thalassemia major (TM)…
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Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective
A significant amount of attention has recently been devoted to the mechanisms involved in hemoglobin (Hb) switching, as it has previously been established that the induction of fetal hemoglobin (HbF)…
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Promoting Adherence to Iron Chelation Treatment in Beta-Thalassemia Patients
Thalassaemia is one of the commonest inherited genetic disorders world-wide with around 25,000 births of the most severely affected transfusion dependent children annually. Patients with transfusion dependent thalassaemia require regular…
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Sickle Cell Disease Related Mortality in Brazil, 2000-2018
Introduction There is a demand to update national mortality trends data related to sickle cell disease (SCD) in Brazil. This study describes causes of death and mortality issues related to…
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l-glutamine, crizanlizumab, voxelotor, and cell-based therapy for adult sickle cell disease: Hype or hope?
For more than two decades, hydroxyurea was the only therapeutic agent approved by the Food and Drug Administration (FDA) for sickle cell disease (SCD). Although curative allogeneic hematopoietic stem cell transplants (allo-HSCT) were also available, only…
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Kidney Stones in Transfusion-Dependent Thalassemia: Prevalence and Risk Factors
As patients with transfusion-dependent thalassemia (TDT) are living longer, novel morbidities are being recognized. The purpose of this review is to summarize the current knowledge regarding the prevalence and risk…
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Global Globin Network Consensus Paper: Classification and Stratified Roadmaps for Improved Thalassaemia Care and Prevention in 32 Countries
The Global Globin Network (GGN) is a project-wide initiative of the Human Variome/Global Variome Project (HVP) focusing on haemoglobinopathies to build the capacity for genomic diagnosis, clinical services, and research…
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Pregnancy Outcomes Among Women Affected with Thalassemia Traits
Objective To compare the maternal and perinatal outcomes between a group of pregnant women diagnosed with thalassemia traits and normal controls. Study design A retrospective cohort study was conducted on…
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Early Detection of Iron Overload Cardiomyopathy in Transfusion Dependent Thalassemia Patients in Sulaimaniyah City, Iraq
Lifelong blood transfusion is recommended for patients with transfusion-dependent thalassemia (TDT) that lead to iron overload and results in cardiomyopathy (CM). The aim of this study is to assess the…
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