Survival
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Scientific Literature
Health‑Related Quality‑of‑Life Impacts Associated with Transfusion‑Dependent β‑Thalassemia in the USA and UK: A Qualitative Assessment
Background: Individuals living with transfusion-dependent β-thalassemia (TDT) experience reduced health-related quality of life due to fatigue and chronic pain, which cause disruptions to daily life. Currently, limited qualitative data exist…
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Scientific Literature
Predicting Factors of Survival Rates Among α-and β-Thalassemia Patients: A Retrospective 10-Year Data Analysis
Background: Thalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications. As genotype interactions lead to variations in the clinical course among patients…
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Scientific Literature
A Cross-Sectional, Multicenter, Disease-Specific, Health-Related Quality of Life study in Greek Transfusion Dependent Thalassemia Patients
The assessment of Health-Related Quality of Life (HRQoL) in Thalassemia offers a holistic approach to the disease and facilitates better communication between physicians and patients. This study aimed to evaluate…
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Scientific Literature
Economic and Clinical Burden of Managing Transfusion-dependent β-Thalassemia in the United States
Aims: To describe clinical complications, treatment use, healthcare resource utilization (HCRU), and costs among patients with transfusion-dependent β-thalassemia (TDT) in the United States. Materials and methods: Merative MarketScan Databases were used to…
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Scientific Literature
Overall and Complication‐free Survival in a Large Cohort of Patients With β‐Thalassemia Major Followed Over 50 Years
We report data on survival and complications for a longitudinal cohort of 709 transfusion-dependent β-thalassemia major patients (51.1% males) born between 1970 and 1997 and followed through 2020 at seven major…
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Scientific Literature
2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia
Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by multidisciplinary teams of experts. Despite the significant…
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Scientific Literature
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Scientific Literature
Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus
Initiation of regular transfusion in transfusion-dependent thalassemia (TDT) is based on the assessment of clinical phenotype. Pathogenic HBB variants causing β-thalassemia are important determinants of phenotype and could be used to aid…
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Scientific Literature
Survival and Causes of Death in 2,033 Patients with Non-Transfusion-Dependent β-Thalassemia
Non-transfusion-dependent β-thalassemia (NTDT) is a broad term encompassing patients who do not require lifelong transfusion therapy for survival. Our understanding of the disease process in NTDT has evolved significantly over…
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Scientific Literature
Management of Age-associated Medical Complications in Patients with β-Thalassemia
Introduction: β-Thalassemia syndromes are among the most common monogenic disorders worldwide. Clinically, on the basis of the severity of the phenotype, β-thalassemias are classified into two groups: transfusion-dependent thalassemia (TDT)…
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