Sickle Cell Disease
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Scientific Literature
Burden of Aging: Health Outcomes Among Adolescents and Young Adults With Sickle Cell Disease
Although ≈95% of children with sickle cell disease (SCD) will reach adulthood in high-income settings, adolescents and young adults (AYA) face difficulties in establishing adult care and experience progression of disease…
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Scientific Literature
Low-dose Warfarin May Be a Life-saving Treatment Regimen in Sickle Cell Diseases
The sickled or just hardened red blood cells (RBCs)-induced capillary endothelial damage initiates at birth, and terminates with multiorgan failures and sudden deaths even at childhood. Although RBCs suspensions and…
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News
PUBLICATION | Travel Guidance for Patients and Families
Welcome to ‘Travel Guidance for Patients & Families’, on the newest TIF’s publications! This practical handbook is intended specifically for travelers with thalassaemia, sickle cell disease, and rare anaemias. Our…
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News
CALL TO ALL PATIENTS | Your Voice Matters in Research!
Today, we invite you to be an active participant in ensuring that research that takes place is aligned with your specific requirements and challenges. Your firsthand experiences as patients offer…
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News
GENE THERAPY | FDA Decision on Lovo-cel for SCD Now Expected by Year’s End
The regulatory agency has agreed to review an application from lovo-cel’s developer, Bluebird Bio, requesting the gene therapy’s approval for SCD patients ages 12 and older. Moreover, the FDA has given the application priority…
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Scientific Literature
Examining Mental Health, Education, Employment, and Pain in Sickle Cell Disease
Importance: Pain related to sickle cell disease (SCD) is complex and associated with social determinants of health. Emotional and stress-related effects of SCD impact daily quality of life and the frequency…
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Scientific Literature
Venous Thromboembolism Prophylaxis in Sickle Cell Disease: A Multicenter Cohort Study of Adolescent Inpatients
Patients with sickle cell disease (SCD) are predisposed to a hypercoagulable state. Despite the increased risk of venous thromboembolism in the SCD population, there is limited evidence available to guide…
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Scientific Literature
Treating Chronic Pain in Sickle Cell Disease: The Need for a Biopsychosocial Model
Chronic pain is the most common complication affecting adults with sickle cell disease (SCD). Pain profoundly affects people’s quality of life, functional ability, and health care utilization. Clinicians are often…
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Scientific Literature
A Novel, Effective, and Efficient Strategy for Treating Sickle Cell Vaso-occlusive Events in the Infusion Center Setting
A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor XII (FXII) triggers activation of…
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News
SICKLE CELL DISEASE | Hydroxyurea Use Linked To Higher Rates Of Spleen Removal
The study’s findings also indicated that SCD children treated with hydroxyurea underwent splenectomy surgery at a significantly younger age compared with those not given the oral medication. That result came…
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