Endocrine system
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Scientific Literature
A Descriptive Preanalytical Survey of Procedures Followed for the Screening of Glucose Dysregulation in Thalassemia Centers: Implications for Clinical Practice and Call for Harmonization
Background: Over the last few decades, screening for dysglycemia in transfusion-dependent β-thalassemia patients (β-TDT) using an oral glucose tolerance test (OGTT) with fasting (FPG) and 2-hour plasma glucose (2h-PG) samples…
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Scientific Literature
Endocrinopathies and Growth in a UK Cohort of Children with Transfusion-Dependent Thalassaemia
Endocrine complications are recognised in transfusion‐dependent thalassaemia (TDT), largely due to iron overload. This is the first study in the United Kingdom evaluating growth and endocrine outcomes in children with…
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Scientific Literature
Growth and Endocrinopathies Among Children with β-Thalassemia Major Treated at Dubai Thalassemia Centre
Background: β-Thalassemia major (BTM) is one of the most common hereditary anemias worldwide. Patients suffer from iron overload that results from repeated blood transfusion This in turn leads to multiple…
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Scientific Literature
Longitudinal study of ICET-A on Glucose Tolerance, Insulin Sensitivity and β-cell Secretion in Eleven β-Thalassemia Major Patients with Mild Iron Overload
Background: Iron chelation therapy (ICT) is the gold standard for treating patients with iron overload, though its long-term effects are still under evaluation. According to current recommendations regarding transfusion-dependent (TD)…
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Scientific Literature
Longitudinal Study of ICET-A on Glucose Tolerance, Insulin Sensitivity and β-cell Secretion in Eleven β-Thalassemia Major Patients With Mild Iron Overload
Background: Iron chelation therapy (ICT) is the gold standard for treating patients with iron overload, though its long-term effects are still under evaluation. According to current recommendations regarding transfusion-dependent (TD) β-thalassemia…
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Scientific Literature
New Entity—Thalassemic Endocrine Disease: Major Beta-Thalassemia and Endocrine Involvement
Beta-thalassemia (BTH), a recessively inherited haemoglobin (Hb) disorder, causes iron overload (IO), extra-medullary haematopoiesis and bone marrow expansion with major clinical impact. The main objective of this review is to…
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Scientific Literature
Glucose Metabolism and Insulin Response to Oral Glucose Tolerance Test (OGTT) in Prepubertal Patients with Transfusion-dependent β-Thalassemia (TDT): A Long-term Retrospective Analysis
Glucose dysregulation (GD), including prediabetes and diabetes mellitus (DM), is a common complication of transfusion-dependent β-thalassemia (TDT) patients. The prevalence increases with age and magnitude of iron overload, affecting a…
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