Scientific Literature
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Optimizing Outcomes snd Accessibility of Matched Sibling Donor Transplant for Transfusion Dependent Thalassemia in LMICs
Abstract Severe thalassemia is a life-threatening condition common in many low- and middle-income countries. While bone marrow transplantation (BMT) offers a curative option, its accessibility remains limited due to cost…
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Long-Term Survival Rates of Thalassemia Patients Following Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis
Abstract Background: Hematopoietic stem cell transplantation is the sole therapeutic approach that can provide a complete cure for thalassemia. However, this procedure is associated with complications that may have life-threatening…
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A Descriptive Preanalytical Survey of Procedures Followed for the Screening of Glucose Dysregulation in Thalassemia Centers: Implications for Clinical Practice and Call for Harmonization
Background: Over the last few decades, screening for dysglycemia in transfusion-dependent β-thalassemia patients (β-TDT) using an oral glucose tolerance test (OGTT) with fasting (FPG) and 2-hour plasma glucose (2h-PG) samples…
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Effects of Vitamin D Deficiency and Supplementation on Myocardial and Hepatic Iron Status and Function in Children with Beta-Thalassemia
Background: This study aimed to evaluate the prevalence of vitamin D deficiency and to assess the effects of vitamin D supplementation on myocardial and hepatic iron burden and organ function…
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Endocrinopathies and Growth in a UK Cohort of Children with Transfusion-Dependent Thalassaemia
Endocrine complications are recognised in transfusion‐dependent thalassaemia (TDT), largely due to iron overload. This is the first study in the United Kingdom evaluating growth and endocrine outcomes in children with…
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Pancreatic Iron Overload Is Associated With Early QTc Prolongation Before Myocardial Iron Deposition in Transfusion-Dependent Thalassemia
Objectives This cross-sectional study evaluated the 12-lead electrocardiogram (ECG) corrected QT (QTc) interval as an accessible marker for organ-specific iron burden in adult patients with transfusion-dependent thalassemia (TDT). Methods We…
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Neutropenia in Adult Patients with Thalassemia Receiving Deferiprone: A 10-Year Experience From a Large Thalassemia Cohort
Background: Deferiprone (DFP) is an effective oral iron chelator widely used in adult patients with thalassemia, particularly for cardiac iron removal. However, DFP is associated with rare but potentially life-threatening…
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Atrial Fibrillation Prevalence and its Management in Aging, Transfusion-Dependent Patients with Thalassemia: The FATHAL Study
Abstract Atrial fibrillation (AF) represents an emerging challenge in thalassemia due to the increasing life expectancy. However, data are limited, and management relies on guidelines for the general population. We…
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MRI-Derived Hepatic Fat and its Clinical Correlates in Non–Transfusion-Dependent Thalassemia: A Cross-Sectional Study
Abstract We quantified hepatic fat fraction (FF) by magnetic resonance imaging (MRI) in non–transfusion-dependent thalassemia (NTDT) patients, and we evaluated its associations with demographic, clinical, and biochemical parameters, tissue iron…
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The Shifting Global Thalassemia Burden and Lessons from Chinese Integrated Control Strategy
Thalassemias impose a substantial but highly uneven global health burden. Using Global Burden of Disease 2023 estimates, we quantified the prevalence, mortality, and disability-adjusted life years (DALYs) of thalassemias across…
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