Scientific Literature
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Global Longitudinal Strain by Cardiac Magnetic Resonance Associated With Cardiac Iron and Complications in β-Thalassemia Major Patients
Background: The aim of this cross-sectional study was to investigate the association of left ventricular (LV) strain parameters with demographics, clinical data, cardiovascular magnetic resonance (CMR) findings, and cardiac complications…
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Revisiting Iron Overload Status and Change Thresholds as Predictors of Mortality in Transfusion-Dependent β-Thalassemia: A 10-year Cohort Study
Data on iron overload status and change thresholds that can predict mortality in patients with transfusion-dependent β-thalassemia (TDT) are limited. This was a retrospective cohort study of 912 TDT patients…
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Global, Regional, and National Burden of Thalassemia, 1990–2021: A Systematic Analysis for the Global Burden of Disease
Background: Anemia is a significant contributor to the global disease burden, of which thalassemia is the most common hereditary anaemic disease. Previous estimates were based on data that were geographically…
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Growth and Endocrinopathies Among Children with β-Thalassemia Major Treated at Dubai Thalassemia Centre
Background: β-Thalassemia major (BTM) is one of the most common hereditary anemias worldwide. Patients suffer from iron overload that results from repeated blood transfusion This in turn leads to multiple…
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Novel Therapeutic Approaches in Thalassemias, Sickle Cell Disease and Other Red Cell Disorders
In this last decade, a deeper understanding of the pathophysiology of hereditary red cell disorders and the development of novel classes of pharmacologic agents have provided novel therapeutic approaches to…
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Health‑Related Quality‑of‑Life Impacts Associated with Transfusion‑Dependent β‑Thalassemia in the USA and UK: A Qualitative Assessment
Background: Individuals living with transfusion-dependent β-thalassemia (TDT) experience reduced health-related quality of life due to fatigue and chronic pain, which cause disruptions to daily life. Currently, limited qualitative data exist…
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Guideline for the Management of Conception and Pregnancy in Thalassaemia Syndromes: A British Society for Haematology Guideline
This comprehensive guideline, developed by a representative group of UK-based medical experts specialising in haemoglobinopathies, addresses the management of conception and pregnancy in patients with thalassaemia. A systematic search of…
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Haemoglobinopathies and Other Rare Anemias in Spain: Ten Years of a Nationwide Registry (REHem-AR)
REHem-AR was created in 2013. The progressive implementation of neonatal screening for haemoglobinopathies in Spanish autonomous communities where the registry had not been implemented, as well as the addition of…
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Predicting Factors of Survival Rates Among α-and β-Thalassemia Patients: A Retrospective 10-Year Data Analysis
Background: Thalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications. As genotype interactions lead to variations in the clinical course among patients…
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An International Learning Collaborative Phase 2 Trial for Haploidentical Bone Marrow Transplant in Sickle Cell Disease
In the setting of a learning collaborative, we conducted an international multicentre phase 2 clinical trial testing the hypothesis that non-myeloablative related haploidentical BMT with thiotepa and post-transplant cyclophosphamide (PTCy)…
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