Publications
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The Shifting Global Thalassemia Burden and Lessons from Chinese Integrated Control Strategy
Thalassemias impose a substantial but highly uneven global health burden. Using Global Burden of Disease 2023 estimates, we quantified the prevalence, mortality, and disability-adjusted life years (DALYs) of thalassemias across…
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Beta‐Thalassemia in Spain: Results From the National Thalassemia Registry and Molecular Analysis of Patients With Transfusion‐Dependent Thalassemia
ABSTRACT Background: Beta-thalassemia is a genetically heterogeneous hemoglobinopathy with marked clinical variability. In Spain, comprehensive nationwide data on transfusion-dependent beta-thalassemia (TDT) remain limited, particularly regarding molecular characterization. Methods: This observational…
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Recent Advances in Thalassemia Management: From Curative Therapies to Artificial Intelligence
Abstract Thalassemia is an inherited hemoglobin disorder characterized by chronic hemolytic anemia and substantial long-term healthcare needs. In β-thalassemia major, patients typically require regular red blood cell transfusions with iron…
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A Multi-Center Clinical Trial of Allogeneic Hematopoietic Stem Cell Transplantation in Transfusion-Dependent Thalassemia
Allogeneic stem cell transplantation (allo-HSCT) has recently been approved as standard therapy for transfusion-dependent thalassemia (TDT) but remains limited to the use of HLA-matched sibling donors (MSDs), due to a…
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National Thalassemia Registry: A 30-year Journey of implementing Carrier Screening in Singapore
Introduction Haemoglobinopathies, which include thalassemia and structural haemoglobin variants, are the most common inherited disease affecting an estimated 20% of the world’s population. Globally, ∼300,000 children are born annually with…
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β-Thalassemia Minor Is Associated With High Rates of Worsening Anemia in Pregnancy
Worsening of anemia because of β-thalassemia minor in pregnancy is not a well-known complication and, when acknowledged, is described as being limited to mild anemia. Knowing that individuals with β-thalassemia…
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Impact of Lifetime Anaemia and Iron Control on Outcomes in Β-Thalassaemia: Data from the Longitudinal de-LIGHT Study
Summary Evidence on the impact of anaemia and iron control on morbidity and mortality in β‐thalassaemia is limited to short‐term studies assessing spot measures. We conducted a retrospective longitudinal cohort…
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Red Cell Specifications for Blood Group Matching in Patients With Haemoglobinopathies: An Updated Systematic Review and Clinical Practice Guideline from the International Collaboration for Transfusion Medicine Guidelines
Summary Red blood cell (RBC) antigen matching beyond ABO and RhD is commonly recommended for patients with sickle cell disease (SCD) and thalassaemia. We present an updated systematic literature review…
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A Guide for the Haemoglobinopathy Nurse
2nd edition. Nicosia (Cyprus): Thalassaemia International Federation; 2025. A comprehensive, practice-oriented reference for nurses involved in the multidisciplinary care of people with thalassaemia and other haemoglobinopathies, developed with contributions from…
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Guidelines for the Management of Thalassaemia Syndromes – Topics in Focus Series (2025)
A series of booklets offering quick access to key recommendations on thalassaemia syndromes, based on TIF's Guidelines on TDT, NTDT, and α-thalassaemia.
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