Publications
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TIF Literature
Socio-economic disparities in clinical outcomes of transfusion-dependent β-thalassaemia patients Avraam D, Angastiniotis M, Soteriades ES, et al. Journal of Health, Population and Nutrition, 2026. Management of transfusion-dependent β-thalassaemia in the…
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Iron Chelation Therapy for Children with Transfusion‐Dependent β‐Thalassemia: How Young Is Too Young?
In this review, we provide a summary of evidence on iron overload in young children with transfusion-dependent β-thalassemia (TDT) and explore the ideal timing for intervention. Key data from clinical…
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Bone Health Impairment in Patients with Hemoglobinopathies: From Biological Bases to New Possible Therapeutic Strategies
Hemoglobinopathies are monogenic disorders affecting hemoglobin synthesis. Thalassemia and sickle cell disease (SCD) are considered the two major hemoglobinopathies. Thalassemia is a genetic disorder and one of the major hemoglobinopathies…
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Early Detection of Renal Complication in Children With Sickle Cell Disease: A Single Center Prospective Study
Introduction: This observational cross-sectional study aimed to identify predictors of renal complications in pediatric patients with sickle cell disease (SCD) at King Salman Armed Forces Hospital, Tabuk, Saudi Arabia, over…
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Hoping for a Normal Life: Decision‐Making on Hematopoietic Stem Cell Transplantation by Patients With a Hemoglobinopathy and Their Caregivers
Background: To provide insight into the perspectives of children and young adults with transfusion-dependent thalassemia and sickle cell disease and their caregivers regarding the decision for hematopoietic stem cell transplantation…
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Liver Disease in Patients With Transfusion-Dependent β-Thalassemia: The Emerging Role of Metabolism Dysfunction-Associated Steatotic Liver Disease
In this Editorial, we highlight the possible role that metabolism dysfunction-associated steatotic liver disease (MASLD) may play in the future, regarding liver disease in patients with transfusion-dependent β-thalassemia (TDBT). MASLD…
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Global Longitudinal Strain by Cardiac Magnetic Resonance Associated With Cardiac Iron and Complications in β-Thalassemia Major Patients
Background: The aim of this cross-sectional study was to investigate the association of left ventricular (LV) strain parameters with demographics, clinical data, cardiovascular magnetic resonance (CMR) findings, and cardiac complications…
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Revisiting Iron Overload Status and Change Thresholds as Predictors of Mortality in Transfusion-Dependent β-Thalassemia: A 10-year Cohort Study
Data on iron overload status and change thresholds that can predict mortality in patients with transfusion-dependent β-thalassemia (TDT) are limited. This was a retrospective cohort study of 912 TDT patients…
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Global, Regional, and National Burden of Thalassemia, 1990–2021: A Systematic Analysis for the Global Burden of Disease
Background: Anemia is a significant contributor to the global disease burden, of which thalassemia is the most common hereditary anaemic disease. Previous estimates were based on data that were geographically…
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Growth and Endocrinopathies Among Children with β-Thalassemia Major Treated at Dubai Thalassemia Centre
Background: β-Thalassemia major (BTM) is one of the most common hereditary anemias worldwide. Patients suffer from iron overload that results from repeated blood transfusion This in turn leads to multiple…
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