α-thalassaemia
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Scientific Literature
In Utero Hematopoietic Cell Transplantation in Fetuses With Α-Thalassemia Major: A Phase 1 Clinical Trial
Abstract In utero hematopoietic cell transplantation (IUHCT) has the potential to treat patients who have hemoglobinopathies by harnessing the unique period of fetal tolerance to maternal cells, thereby enabling semi-allogeneic…
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Scientific Literature
Transforming The Treatment of Alpha-Thalassemia: A Single-Center Retrospective Study on Hematopoietic Stem Cell Transplantation in Transfusion-Dependent Pediatric Patients
Abstract Hematopoietic stem cell transplantation (HSCT) is the only definitive cure for transfusion-dependent α-thalassemia, though comprehensive studies on its effectiveness are limited. In this retrospective study, we analyzed the clinical…
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Scientific Literature
Disease-Related Complications and Risk Factors in Hemoglobin H Disease in a Thai Multicentre Registry
Abstract Hemoglobin H (Hb H) disease is a prevalent hereditary hemolytic anemia worldwide. Clinical severity varies by genotype, particularly between deletional and non-deletional forms, as well as the presence of…
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Scientific Literature
Systematic Review and Evidence Gap Assessment of the Clinical, Quality of Life, and Economic Burden of Alpha-Thalassemia
A recent evidence gaps assessment of the clinical, health-related quality of life, and economic burden associated with α-thalassemia is lacking. We conducted a systematic literature review (SLR) following the methodological…
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Scientific Literature
Alpha-Thalassemia: A Practical Overview
α-Thalassemia is an inherited blood disorder characterized by decreased synthesis of α-globin chains that results in an imbalance of α and β globin and thus varying degrees of ineffective erythropoiesis, decreased red blood cell (RBC)…
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News
EXCLUSIVE WEBINAR | Guidelines for the Management of a-Thalassaemia |14 March 2024
📌 Webinar Title: Guidelines for the Management of α-Thalassaemia 📌 Date & Time: Thursday, March 14, 2024, 13:00 Bangkok / 07:00 Paris / 22:00 PST This session aims to…
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News
BREAKING NEW GROUND | The First-Ever Guidelines for Managing α-Thalassaemia
The Thalassaemia International Federation (TIF) is proud to present the first international-level guidelines for the management of a-thalassaemia, a comprehensive and indispensable resource for health professionals, researchers and all those…
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Scientific Literature
Αlpha-thalassemia Genotypes in Vietnam: A Report of 12,030 Pregnant Women and Their Husbands Performing Prenatal Screening for Alpha-thalassemia
BACKGROUND: Αlpha (α)-thalassemia is a global health concern, and improving screening methods is crucial for disease prevention. This study aimed to assess α-thalassemia genotypes and evaluate the effectiveness of various…
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News
PYRUVATE KINASE DEFICIENCY | FDA Approves First Drug For The Rare Inherited Anemia
The US Food and Drug Administration (FDA) has announced the approval of Mitapivat (PYRUKYND®) tablets as treatment for haemolytic anemia in adults with pyruvate kinase (PK) deficiency. The oral PK…
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TIF Publications
Beta Thalassaemia, Alpha Thalassaemia and Sickle Cell Disease – Educational Community Booklet (2014)
Eleftheriou A., Angastiniotis M.
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