Scientific Literature

Survival and Causes of Death in 2,033 Patients with Non-Transfusion-Dependent β-Thalassemia

Musallam, K. M., Vitrano, A., Meloni, A., et al. (2021). Haematologica, 106(9), 2489. (2021)

Non-transfusion-dependent β-thalassemia (NTDT) is a broad term encompassing patients who do not require lifelong transfusion therapy for survival. Our understanding of the disease process in NTDT has evolved significantly over the past two decades and it is now established that a diagnosis of NTDT can be associated with greater morbidity than previously recognized.

The aim of the current study was to evaluate survival and causes of death in a large cohort of patients with NTDT. Considering the high variability in management practices, the impacts of transfusion and iron chelation therapy on mortality outcomes were also examined.

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