Scientific Literature

Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management

Malagù, M., Marchini, F., Fiorio, A.,et al. Biology, 11(1), 148. (2022)

Atrial fibrillation in patients with β-thalassemia has a higher incidence compared to the general population. Its pathophysiology is peculiar and strictly related to anemia, iron overload, hemolysis, inflammation, atrial dilatation, fibrosis, and remodelling.

The clinical presentation is that of a highly symptomatic disease with frequent recurrences, significantly impacting over quality of life and prognosis. Furthermore, the risk of thromboembolic events and stroke is considerable. The available treatments are drug therapy and transcatheter ablation.

Moreover, particular attention should be paid to anticoagulant therapy for thromboembolic prophylaxis.

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