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Although chronic blood transfusion regimens have added decades to the lives of patients with thalassaemia, clinicians are now faced with increasingly complicated management challenges.
The devastating effect of the accumulated iron from chronic blood transfusions necessitates a more finely tuned approach to limit the complications of the disease, as well as its treatment.
Survival in transfusion-dependent thalassemia patients can be improved with proper understanding of the pathophysiology of thalassemia and iron toxicity, comprehensive transfusion protocols, accurate measurements of total body iron, and employment of strategies to reduce iron burden.